An open tool for input function estimation and quantification of dynamic PET FDG brain scans
Martín Bertrán, Natalia Martínez, Guillermo Carbajal, Alicia Fernández, Alvaro Gómez
International Journal of Computer Assisted Radiology and Surgery, Volume 11, Number 8, page 1419--1430 - Aug. 2016
Research Group(s): Tratamiento de Imagenes (gti)
Department(s): Procesamiento de Señales
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Abstract

Positron emission tomography (PET) analysis of clinical studies is mostly restricted to qualitative evaluation. Quantitative analysis of PET studies is highly desirable to be able to compute an objective measurement of the process of interest in order to evaluate treatment response and/or compare patient data. But implementation of quantitative analysis generally requires the determination of the input function: the arterial blood or plasma activity which indicates how much tracer is available for uptake in the brain. The purpose of our work was to share with the community an open software tool that can assist in the estimation of this input function, and the derivation of a quantitative map from the dynamic PET study.

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» Martín Bertrán
» Natalia Martínez
» Guillermo Carbajal
» Alicia Fernández
» Alvaro Gómez